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Literature summary for 3.4.22.15 extracted from

  • Minokadeh, A.; Funkelstein, L.; Toneff, T.; Hwang, S.R.; Beinfeld, M.; Reinheckel, T.; Peters, C.; Zadina, J.; Hook, V.
    Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression (2010), Mol. Cell. Neurosci., 43, 98-107.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory vesicle
-
Mus musculus 99503
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
cerebral cortical neuron
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
CatL
-
Mus musculus

General Information

General Information Comment Organism
malfunction cathepsin L knockout mouse brains show extensive decreases in dynorphin A, dynorphin B, and alpha-neoendorphin that are reduced by 75%, 83%, and 90%, respectively Mus musculus
physiological function cathepsin L plays a prominent role, jointly with PC1/3 and PC2, for production of dynorphins in brain Mus musculus