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Literature summary for 3.4.22.15 extracted from

  • Shenoy, R.T.; Chowdhury, S.F.; Kumar, S.; Joseph, L.; Purisima, E.O.; Sivaraman, J.
    A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors (2009), J. Med. Chem., 52, 6335-6346.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitor biphenylacetyl-(Nepsilon-biphenylacetyl)-L-Lys-D-Arg-L-Tyr-N-phenylethyl, hanging drop vapor diffusion method, using 19%(w/v) polyethylene glycol 8000 and 200 mM ammonium sulfate, or in complex with inhibitor biphenylacetyl-(Nepsilon-biphenylacetyl)L-Lys-D-Arg-L-Phe-N-phenylethyl hanging drop vapor diffusion method, using 25% (w/v) polyethylene glycol 8000 and 200 mM ammonium sulfate, or in complex with biphenylacetyl-M-Cys-D-Arg-L-Phe-N-phenylethyl, hanging drop vapor diffusion method, using 30% (w/v) polyethylene glycol 8000 and 200 mM ammonium sulfate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
biphenylacetyl-(N6-biphenylacetyl)-Lys-D-Arg-Tyr-N-phenylethyl
-
Homo sapiens
biphenylacetyl-(N6-biphenylacetyl)Lys-D-Arg-Phe-N-phenylethyl
-
Homo sapiens
biphenylacetyl-MCys-D-Arg-Phe-N-phenylethyl
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P07711
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000019
-
biphenylacetyl-MCys-D-Arg-Phe-N-phenylethyl pH and temperature not specified in the publication Homo sapiens
0.000023
-
biphenylacetyl-(N6-biphenylacetyl)-Lys-D-Arg-Tyr-N-phenylethyl pH and temperature not specified in the publication Homo sapiens
0.000511
-
biphenylacetyl-(N6-biphenylacetyl)Lys-D-Arg-Phe-N-phenylethyl pH and temperature not specified in the publication Homo sapiens