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Literature summary for 3.4.22.15 extracted from

  • Konjar, S.; Sutton, V.R.; Hoves, S.; Repnik, U.; Yagita, H.; Reinheckel, T.; Peters, C.; Turk, V.; Turk, B.; Trapani, J.A.; Kopitar-Jerala, N.
    Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L (2010), Immunology, 131, 257-267.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-L-Phe-L-Phe-fluoromethylketone
-
Homo sapiens
benzyloxycarbonyl-L-Phe-L-Phe-fluoromethylketone
-
Mus musculus
E-64d
-
Homo sapiens
E-64d
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Mus musculus 5764
-
lysosome
-
Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
perforin + H2O Mus musculus CatL preferentially cleaves a site on full-length recombinant perforin close to its C terminus ?
-
?
perforin + H2O Homo sapiens CatL preferentially cleaves a site on full-length recombinant perforin close to its C terminus ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cytotoxic T-lymphocyte
-
Mus musculus
-
natural killer cell
-
Homo sapiens
-
NK-92 cell
-
Homo sapiens
-
YT cell YT 5 cell Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
-
Mus musculus benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
?
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
?
perforin + H2O CatL preferentially cleaves a site on full-length recombinant perforin close to its C terminus Mus musculus ?
-
?
perforin + H2O CatL preferentially cleaves a site on full-length recombinant perforin close to its C terminus Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
CatL
-
Mus musculus
CatL
-
Homo sapiens

General Information

General Information Comment Organism
physiological function granule-bound cathepsins are essential for processing perforin to its active form, and CatL is an important, but not exclusive, participant in this process Mus musculus
physiological function granule-bound cathepsins are essential for processing perforin to its active form, and CatL is an important, but not exclusive, participant in this process Homo sapiens