Literature summary for 3.4.22.15 extracted from

Zeeuwen, P.L.; van Vlijmen-Willems, I.M.; Cheng, T.; Rodijk-Olthuis, D.; Hitomi, K.; Hara-Nishimura, I.; John, S.; Smyth, N.; Reinheckel, T.; Hendriks, W.J.; Schalkwijk, J.
The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea (2010), FASEB J., 24, 3744-3755.

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Inhibitors

Inhibitors	Comment	Organism	Structure
benzyloxycarbonyl-PheTyr-[tert-butyl]-diazomethylketone	specific inhibitor	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-L-Leu-L-Arg-7-amido-4-methylcoumarin + H2O	-	Mus musculus	benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-methylcoumarin	-	?

General Information

General Information	Comment	Organism
malfunction	ablation of cathepsin L in a cystatin M/E-deficient background (Cst6-/-Ctsl-/-double-knockout mice) restores viability and results in normalization of stratum corneum morphology	Mus musculus
physiological function	the cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea. Activation of cathepsin D and transglutaminase-1 are downstream events, dependent of cathepsin L activity	Mus musculus

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Release 2023.1 (January 2023)