Literature summary for 3.4.22.15 extracted from

Tang, Q.; Cai, J.; Shen, D.; Bian, Z.; Yan, L.; Wang, Y.X.; Lan, J.; Zhuang, G.Q.; Ma, W.Z.; Wang, W.
Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling (2009), J. Mol. Med., 87, 249-260.

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Application

Application	Comment	Organism
medicine	cathepsin L expression in cardiomyocytes blunts cardiac hypertrophy through blocking of Akt/GSK3beta signaling. Constitutive cardiac over-expression of cathepsin L in mice attenuates the hypertropic response, markedly reduces apoptosis, and fibrosis	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
cardiac over-expression in mice	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	constitutive cardiac over-expression in mice attenuates the hypertropic response, markedly reduces apoptosis, and fibrosis. Cardiac function is also preserved in hearts with increased cathepsin L levels in response to hypertropic stimuli, associated with attenuation of the Akt/GSK3beta signaling cascade	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)