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Literature summary for 3.4.22.15 extracted from

  • Thomas, V.; Samanta, S.; Fikrig, E.
    Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function (2008), Infect. Immun., 76, 4905-4912.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine infection of HL-60 cells with Anaplasma phagocytophilum results in elevated cathepsin L activity and the proteolysis of CDP. Blocking the action of cathepsin L with a chemical inhibitor or siRNA causes a marked reduction in the degree of Anaplasma phagocytophilum infection. Increasing cathepsin L activity is a strategy used by Anaplasma phagocytophilum to alter CDP activity and thereby globallly influence neutrophil function Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 infected with Anaplasma phagocytophilum
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Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell infection with Anaplasma phagocytophilum results in elevated cathepsin L activity and the proteolysis of CDP Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(benzyloxycarbonyl-Phe-Arg)2-R110 + H2O rhodamine-labeled substrate Homo sapiens ?
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 ?