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Literature summary for 3.4.22.15 extracted from
- The role of conserved residues of chagasin in the inhibition of cysteine peptidases (2008), FEBS Lett., 582, 485-490.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chagasin | - |
Homo sapiens | |
| chagasin mutant delta T31-T32 | - |
Homo sapiens | |
| chagasin mutant P30A | - |
Homo sapiens | |
| chagasin mutant T31A | - |
Homo sapiens | |
| chagasin mutant T31A/T32A | - |
Homo sapiens | |
| chagasin mutant T31S | - |
Homo sapiens | |
| chagasin mutant T31V | - |
Homo sapiens | |
| chagasin mutant T31Y | - |
Homo sapiens | |
| chagasin mutant T32A | - |
Homo sapiens | |
| chagasin mutant T32S | - |
Homo sapiens | |
| chagasin mutant T32V | - |
Homo sapiens | |
| chagasin mutant T32Y | - |
Homo sapiens | |
| chagasin mutant W93A | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Z-Phe-Arg-7-amido-4-methyl-coumarin + H2O | 5 microM, pH 6.5, 28°C | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cathepsin L | - |
Homo sapiens |
| human cathepsin L | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 28 | - |
assay at pH 6.5 | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at 28°C | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000000018 | - |
chagasin mutant T31A/T32A | - |
Homo sapiens | |
| 0.0000000027 | - |
chagasin mutant T32Y | - |
Homo sapiens | |
| 0.0000000039 | - |
chagasin mutant T31A | - |
Homo sapiens | |
| 0.0000000049 | - |
chagasin mutant T31S | - |
Homo sapiens | |
| 0.0000000068 | - |
chagasin mutant T31Y | - |
Homo sapiens | |
| 0.0000000073 | - |
chagasin | - |
Homo sapiens | |
| 0.0000000097 | - |
chagasin mutant T31V | - |
Homo sapiens | |
| 0.000000014 | - |
chagasin mutant T32A | - |
Homo sapiens | |
| 0.00000002 | - |
chagasin mutant T32V | - |
Homo sapiens | |
| 0.000000032 | - |
chagasin mutant T32S | - |
Homo sapiens | |
| 0.000000045 | - |
chagasin mutant P30A | - |
Homo sapiens | |
| 0.000000825 | - |
chagasin mutant W93A | - |
Homo sapiens | |
| 0.0000022 | - |
chagasin mutant deltaT31-T32 | - |
Homo sapiens |
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