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Literature summary for 3.4.22.15 extracted from

  • Zheng, X.; Chu, F.; Mirkin, B.L.; Sudha, T.; Mousa, S.A.; Rebbaa, A.
    Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy (2008), Biochim. Biophys. Acta, 1783, 2294-2300.
    View publication on PubMed
Search for more literature for 3.4.22.15

Protein Variants

Protein Variants Comment Organism
additional information cathepsin L inhibition by siRNA triggers autophagy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-nathalenesulfonyl-Ile-Trp-CHO treatment of cells results in suppression of cellular proliferation and the induction of a cell death with no detecable caspase-3 activation or DNA fragmentation. Cell death is associated with increased accumulation of cathepsin D, cellular vacuolization, expression of the mannose 6-phosphate recepto, and the autophagy marker LC-II Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cathepsin L has a pro-survival function within the cell which may be due, at least in part, to its ability to deplete the cells from the proapoptotic molecule caspase-3. The existence of a proteolytic hierarchy between pro-survival and pro-death proteases suggests that changes in cellular proteolytic profiles are likely to have significant consequences not only on its survival but also on the type of death it may undergo in response to a specific stress ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant product Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cathepsin D + H2O
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 Homo sapiens ?
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 ?
additional information cathepsin L has a pro-survival function within the cell which may be due, at least in part, to its ability to deplete the cells from the proapoptotic molecule caspase-3. The existence of a proteolytic hierarchy between pro-survival and pro-death proteases suggests that changes in cellular proteolytic profiles are likely to have significant consequences not only on its survival but also on the type of death it may undergo in response to a specific stress Homo sapiens ?
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 ?