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Literature summary for 3.4.22.15 extracted from

  • Cheng, T.; Hitomi, K.; van Vlijmen-Willems, I.M.; de Jongh, G.J.; Yamamoto, K.; Nishi, K.; Watts, C.; Reinheckel, T.; Schalkwijk, J.; Zeeuwen, P.L.
    Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification (2006), J. Biol. Chem., 281, 15893-15899.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cystatin A
-
Homo sapiens
cystatin B
-
Homo sapiens
cystatin C
-
Homo sapiens
cystatin D
-
Homo sapiens
cystatin F
-
Homo sapiens
cystatin M/E
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Leu-Arg-4-methylcoumarin 7-amide + H2O
-
Homo sapiens benzyloxycarbonyl-Leu-Arg + 7-amino-4-methyl-coumarin
-
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Synonyms

Synonyms Comment Organism
cathepsin L
-
Homo sapiens
CTSL
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000005
-
cystatin A 0.1 M acetate pH 5.5, 1 mM EDTA, 2 mM dithiothreitol, 100 mg/ml bovine serum albumin, 10 min Homo sapiens
0.00000005
-
cystatin B 0.1 M acetate pH 5.5, 1 mM EDTA, 2 mM dithiothreitol, 100 mg/ml bovine serum albumin, 10 min Homo sapiens
0.00000008
-
cystatin C 0.1 M acetate pH 5.5, 1 mM EDTA, 2 mM dithiothreitol, 100 mg/ml bovine serum albumin, 10 min Homo sapiens
0.00000049
-
cystatin F 0.1 M acetate pH 5.5, 1 mM EDTA, 2 mM dithiothreitol, 100 mg/ml bovine serum albumin, 10 min Homo sapiens
0.00000178
-
cystatin M/E 0.1 M acetate pH 5.5, 1 mM EDTA, 2 mM dithiothreitol, 100 mg/ml bovine serum albumin, 10 min Homo sapiens
0.00000281
-
cystatin D 0.1 M acetate pH 5.5, 1 mM EDTA, 2 mM dithiothreitol, 100 mg/ml bovine serum albumin, 10 min Homo sapiens