Literature summary for 3.4.22.15 extracted from

Nishimura, Y.; Furuno, K.; Kato, K.
Biosynthesis and processing of lysosomal cathepsin L in primary cultures of rat hepatocytes (1988), Arch. Biochem. Biophys., 263, 107-116.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	the enzyme is initially synthesized on membrane-bound polysomes as a 37500 Da prepropeptide. The cotranslational cleavage of the 1500 Da signal peptide and the core glycosylation convert the precursor to the 39000 Da proform, which is subsequently processed to the mature form during biosynthesis	Rattus norvegicus
side-chain modification	precursor and mature enzyme are N-glycosylated with high-mannose-type oligosaccharides	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	primary culture	Rattus norvegicus	-

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Release 2023.1 (January 2023)