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Literature summary for 3.4.22.15 extracted from

  • Reilly, J.J.; Mason, R.W.; Chen, P.; Joseph, L.J.; Sukhatme, V.P.; Yee, R.; Chapman, H.A.
    Synthesis and processing of cathepsin L, an elastase, by human alveolar macrophages (1989), Biochem. J., 257, 493-498.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens differentiation of human macrophages within the lung is accompanied by synthesis and expression of cathepsin L ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the precursor cathepsin of 43000 Da is processed via a 34000 Da intermediate to the 25000 Da mature form. The 43000 Da precursor is secreted and some is also membrane-bound Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
alveolar macrophage from lungs of healthy adults Homo sapiens
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liver
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Phe-Ala-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
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 ?
additional information differentiation of human macrophages within the lung is accompanied by synthesis and expression of cathepsin L Homo sapiens ?
-
 ?