Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
253J-BV cell | - |
Homo sapiens | - |
253J-P cell | - |
Homo sapiens | - |
bladder transitional cell carcinoma cell | - |
Homo sapiens | - |
epithelium | prostasin is expressed abundantly in normal epithelia | Homo sapiens | - |
HT-1376 cell | - |
Homo sapiens | - |
J-82 cell | - |
Homo sapiens | - |
KU-7 cell | - |
Homo sapiens | - |
RT-4 cell | - |
Homo sapiens | - |
T-24 cell | - |
Homo sapiens | - |
UM-UC-10 cell | - |
Homo sapiens | - |
UM-UC-14 cell | - |
Homo sapiens | - |
UM-UC-3 cell | - |
Homo sapiens | - |
UM-UC-5 cell | - |
Homo sapiens | - |
UM-UC-9 cell | - |
Homo sapiens | - |
urothelium | - |
Homo sapiens | - |
UROtsa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin + H2O | - |
Homo sapiens | acetyl-PRLR + 7-amino-4-carbamoylmethylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PRSS8 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | prostasin is down-regulated in human prostate, breast, and gastric cancers and invasive cancer cell lines | down |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of prostasin expression in the transitional cell carcinoma cell lines is correlated with loss of or reduced E-cadherin expression, loss of epithelial morphology, and promoter DNA hypermethylation and may have functional implications in tumor invasion and resistance to chemotherapy | Homo sapiens |
physiological function | prostasin is essential for terminal epithelial differentiation, prostasin is involved in the extracellular proteolytic modulation of the epidermal growth factor receptor and is an invasion suppressor | Homo sapiens |