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Literature summary for 3.4.21.B6 extracted from

  • Chen, L.; Verity, N.; Chai, K.
    Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT) (2009), BMC Cancer, 9, 377.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
253J-BV cell
-
Homo sapiens
-
253J-P cell
-
Homo sapiens
-
bladder transitional cell carcinoma cell
-
Homo sapiens
-
epithelium prostasin is expressed abundantly in normal epithelia Homo sapiens
-
HT-1376 cell
-
Homo sapiens
-
J-82 cell
-
Homo sapiens
-
KU-7 cell
-
Homo sapiens
-
RT-4 cell
-
Homo sapiens
-
T-24 cell
-
Homo sapiens
-
UM-UC-10 cell
-
Homo sapiens
-
UM-UC-14 cell
-
Homo sapiens
-
UM-UC-3 cell
-
Homo sapiens
-
UM-UC-5 cell
-
Homo sapiens
-
UM-UC-9 cell
-
Homo sapiens
-
urothelium
-
Homo sapiens
-
UROtsa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin + H2O
-
Homo sapiens acetyl-PRLR + 7-amino-4-carbamoylmethylcoumarin
-
?

Synonyms

Synonyms Comment Organism
PRSS8
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens prostasin is down-regulated in human prostate, breast, and gastric cancers and invasive cancer cell lines down

General Information

General Information Comment Organism
malfunction loss of prostasin expression in the transitional cell carcinoma cell lines is correlated with loss of or reduced E-cadherin expression, loss of epithelial morphology, and promoter DNA hypermethylation and may have functional implications in tumor invasion and resistance to chemotherapy Homo sapiens
physiological function prostasin is essential for terminal epithelial differentiation, prostasin is involved in the extracellular proteolytic modulation of the epidermal growth factor receptor and is an invasion suppressor Homo sapiens