Application | Comment | Organism |
---|---|---|
diagnostics | hypermethylated KLK10 is frequent in hepatocellular carcinoma and may be useful as marker for clinical application | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene KLK10, located at 19q13.3-q13.4, quantitative real-time PCR expression analysis, determination of DNA hypermethylation status of KLK10 in hepatocellular carcinoma cell lines and clinical samples, DNA methylation profiles, overview. Ectopic expression of KLK10 enhances drug sensitivity of HuH7 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
hepatocellular carcinoma cell | hypermethylated KLK10 is frequent in hepatocellular carcinoma | Homo sapiens | - |
Huh-7 cell | - |
Homo sapiens | - |
J7 hepatoma cell | - |
Homo sapiens | - |
Mahlavu cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
kallikrein-related peptidase 10 | - |
Homo sapiens |
KLK10 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | KLK10 hypermethylation is significantly associated with cirrhosis and HCV infection as well as inversely associated with HBV infection. Restoration of KLK10 expression, by 5-aza-cytidine treatment, reduces the ability of anchorage-independent growth, and sensitizes hepatocellular carcinoma cells to doxorubicin- or 5-fluorouracil-induced cytotoxicity | Homo sapiens |