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Literature summary for 3.4.21.89 extracted from

  • Ollinger, J.; OMalley, T.; Ahn, J.; Odingo, J.; Parish, T.
    Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions (2012), J. Bacteriol., 194, 2614-2619.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
K174A mutation is lethal Mycobacterium tuberculosis
S94A mutation is lethal Mycobacterium tuberculosis
S96A mutation is lethal Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one overexpression of lepB reduces the susceptibility of Mycobacterium tuberculosis to 1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one, and downregulation results in increased susceptibility. Treatment with 1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one leads to a rapid loss of viability and cell lysis. The compound has increased potency in nonreplicating cells, causing a reduction in viable cell numbers below the detection limit after 24 h Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WKA1
-
-
Mycobacterium tuberculosis H37Rv P9WKA1
-
-

Synonyms

Synonyms Comment Organism
LepB
-
 Mycobacterium tuberculosis
Rv2903c
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function gene is essential, and reduced lepB expression is detrimental to growth Mycobacterium tuberculosis