Literature summary for 3.4.21.89 extracted from

Taheri, T.; Salmanian, A.H.; Gholami, E.; Doustdari, F.; Zahedifard, F.; Rafati, S.
Leishmania major: Disruption of signal peptidase type I and its consequences on survival, growth and infectivity (2010), Exp. Parasitol., 126, 135-145.

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Protein Variants

Protein Variants	Comment	Organism
additional information	construction of a null mutant of SPase I is not possible, suggesting that SPase I is an essential gene for parasite survival. The obtained heterozygote mutant by disrupting one allele of SPase I show significantly reduced level of infectivity in bone marrow-derived macrophages. The heterozygote mutants are unable to cause cutaneous lesion in susceptible BALB/c mice. Comparison of in vivo infectivity potential of DELTAspase::NEO/SPase heterozygote mutant and wild-type parasites, overview	Leishmania major

Organism

Organism	UniProt	Comment	Textmining
Leishmania major	-	strain MHOM/IL/81, isolated from footpad lesions of infected BALB/c mice	-
Leishmania major MHOM/IL/80/Friedlin	-	strain MHOM/IL/81, isolated from footpad lesions of infected BALB/c mice	-

Synonyms

Synonyms	Comment	Organism
signal peptidase type I	-	Leishmania major
Spase I	-	Leishmania major

General Information

General Information	Comment	Organism
physiological function	SPase I is responsible for removing the signal peptide from secretory pre-proteins and releasing mature proteins to cellular or extra-cellular space. SPase I may have an important role in Leishmania infectivity, e.g. in differentiation and survival of amastigotes	Leishmania major

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Release 2023.1 (January 2023)