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Literature summary for 3.4.21.89 extracted from

  • Muller, M.
    Proteolysis in protein import and export: signal peptide processing in eu- and prokaryotes (1992), Experientia, 48, 118-129.
    View publication on PubMed
Search for more literature for 3.4.21.89

Inhibitors

Inhibitors Comment Organism Structure
additional information a mutant maltose-binding protein species with Pro at the +1 position interferes with the activity of signal peptidase in vivo, the mutant protein is not processed at either the normal site or an upstream alternate site previously identified, induced synthesis of this protein is inhibitory to cell growth and causes a pleiotrophic defect in processing of all nonlipoprotein precursors examined Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast stroma
-
 Pisum sativum 9570
-
cytoplasmic membrane bacteria Escherichia coli
-
-
endoplasmic reticulum rough ER microsomes Gallus gallus 5783
-
endoplasmic reticulum rough ER microsomes Saccharomyces cerevisiae 5783
-
endoplasmic reticulum rough ER microsomes Canis lupus familiaris 5783
-
mitochondrial inner membrane
-
 Saccharomyces cerevisiae 5743
-
mitochondrial matrix
-
 Rattus norvegicus 5759
-
mitochondrial matrix
-
 Saccharomyces cerevisiae 5759
-
mitochondrial matrix
-
 Neurospora crassa 5759
-
thylakoid
-
 Pisum sativum 9579
-
thylakoid chloroplast Pisum sativum 9579
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
12000
-
 1 * 25000 + 1 * 22000-23000 (a glycoprotein) + 1 * 21000 + 1 * 18000 + 1 * 12000, dog, SDS-PAGE Canis lupus familiaris
13000
-
 1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE Escherichia coli
13000
-
 1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE Saccharomyces cerevisiae
18000
-
 1 * 25000 + 1 * 22000-23000 (a glycoprotein) + 1 * 21000 + 1 * 18000 + 1 * 12000, dog, SDS-PAGE Canis lupus familiaris
18000
-
 1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE Escherichia coli
18000
-
 1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE Saccharomyces cerevisiae
19000
-
 1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE Gallus gallus
19000
-
 1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE Rattus norvegicus
19000
-
 1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE Saccharomyces cerevisiae
19000
-
 1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE Neurospora crassa
20000
-
 1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE Escherichia coli
20000
-
 1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE Saccharomyces cerevisiae
21000
-
 1 * 25000 + 1 * 22000-23000 (a glycoprotein) + 1 * 21000 + 1 * 18000 + 1 * 12000, dog, SDS-PAGE Canis lupus familiaris
25000
-
 1 * 25000 + 1 * 22000-23000 (a glycoprotein) + 1 * 21000 + 1 * 18000 + 1 * 12000, dog, SDS-PAGE Canis lupus familiaris
25000
-
 1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE Escherichia coli
25000
-
 1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE Saccharomyces cerevisiae
48000
-
 1 * 51000 + 1 * 48000, yeast, SDS-PAGE Gallus gallus
48000
-
 1 * 51000 + 1 * 48000, yeast, SDS-PAGE Rattus norvegicus
48000
-
 1 * 51000 + 1 * 48000, yeast, SDS-PAGE Saccharomyces cerevisiae
48000
-
 1 * 51000 + 1 * 48000, yeast, SDS-PAGE Neurospora crassa
51000
-
 1 * 51000 + 1 * 48000, yeast, SDS-PAGE Gallus gallus
51000
-
 1 * 51000 + 1 * 48000, yeast, SDS-PAGE Rattus norvegicus
51000
-
 1 * 51000 + 1 * 48000, yeast, SDS-PAGE Saccharomyces cerevisiae
51000
-
 1 * 51000 + 1 * 48000, yeast, SDS-PAGE Neurospora crassa
52000
-
 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE Gallus gallus
52000
-
 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE Rattus norvegicus
52000
-
 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE Saccharomyces cerevisiae
52000
-
 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE Neurospora crassa
52000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Gallus gallus
52000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Rattus norvegicus
52000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Saccharomyces cerevisiae
52000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Neurospora crassa
55000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Gallus gallus
55000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Rattus norvegicus
55000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Saccharomyces cerevisiae
55000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Neurospora crassa
57000
-
 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE Gallus gallus
57000
-
 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE Rattus norvegicus
57000
-
 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE Saccharomyces cerevisiae
57000
-
 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE Neurospora crassa

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Escherichia coli
-
-
-
Gallus gallus
-
-
-
Neurospora crassa
-
-
-
Pisum sativum
-
 pea
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
oviduct
-
 Gallus gallus
-
pancreas
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information specificity overview Gallus gallus ?
-
 ?
additional information specificity overview Escherichia coli ?
-
 ?
additional information specificity overview Rattus norvegicus ?
-
 ?
additional information specificity overview Saccharomyces cerevisiae ?
-
 ?
additional information specificity overview Neurospora crassa ?
-
 ?
additional information specificity overview Pisum sativum ?
-
 ?
additional information specificity overview Canis lupus familiaris ?
-
 ?
additional information a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site Gallus gallus ?
-
 ?
additional information a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site Escherichia coli ?
-
 ?
additional information a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site Rattus norvegicus ?
-
 ?
additional information a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site Saccharomyces cerevisiae ?
-
 ?
additional information a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site Neurospora crassa ?
-
 ?
additional information a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site Pisum sativum ?
-
 ?
additional information a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site Canis lupus familiaris ?
-
 ?

Subunits

Subunits Comment Organism
? 1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE Escherichia coli
? 1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE Saccharomyces cerevisiae
dimer 1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE Gallus gallus
dimer 1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE Rattus norvegicus
dimer 1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE Saccharomyces cerevisiae
dimer 1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE Neurospora crassa
dimer 1 * 51000 + 1 * 48000, yeast, SDS-PAGE Gallus gallus
dimer 1 * 51000 + 1 * 48000, yeast, SDS-PAGE Rattus norvegicus
dimer 1 * 51000 + 1 * 48000, yeast, SDS-PAGE Saccharomyces cerevisiae
dimer 1 * 51000 + 1 * 48000, yeast, SDS-PAGE Neurospora crassa
dimer 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE Gallus gallus
dimer 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE Rattus norvegicus
dimer 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE Saccharomyces cerevisiae
dimer 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE Neurospora crassa
dimer 1 * 52000 + 1 * 55000, SDS-PAGE Gallus gallus
dimer 1 * 52000 + 1 * 55000, SDS-PAGE Rattus norvegicus
dimer 1 * 52000 + 1 * 55000, SDS-PAGE Saccharomyces cerevisiae
dimer 1 * 52000 + 1 * 55000, SDS-PAGE Neurospora crassa
pentamer 1 * 25000 + 1 * 22000-23000 (a glycoprotein) + 1 * 21000 + 1 * 18000 + 1 * 12000, dog, SDS-PAGE Canis lupus familiaris