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Literature summary for 3.4.21.75 extracted from

  • Fu, J.; Zhang, J.; Gong, Y.; Testa, C.L.; Klein-Szanto, A.J.
    Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells (2015), Mol. Carcinog., 54, 698-706.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.75

Organism

Organism UniProt Comment Textmining
Homo sapiens P09958
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Source Tissue

Source Tissue Comment Organism Textmining
A-253 cell
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 Homo sapiens
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Detroit 562 cell
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 Homo sapiens
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squamous cell carcinoma cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
PCSK3
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 Homo sapiens

General Information

General Information Comment Organism
evolution the enzyme belongs to the family of serine proteases Homo sapiens
malfunction furin siRNAs upregulate HIF-1alpha protein under normoxic condition to a level similar to that obtained by cobalt chloride treatment, eventually leading to activation of VEGF-A synthesis in two human head and neck squamous cell carcinoma cell lines. HIF-1alpha induction of the enzyme siRNAs and either cobalt chloride or the 26S ribosome inhibitor, MG-132, suggesting a post-transcriptional enzyme-mediated regulation, the induction by siRNAs is inhibited by a specific IGF-1R signaling inhibitor Homo sapiens
physiological function regulation of HIF-1 alpha, a major transcription factor involved in tumorigenesis by sensing intratumoral hypoxia, by the proprotein convertases furin and PC7 in human squamous carcinoma cells, overview. Furin is one of the numerous target genes regulated by HIF-1alpha transactivation and its distribution into endosomal compartments and onto the cell surface can be triggered by hypoxia via HIF-1alpha, overview Homo sapiens