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Literature summary for 3.4.21.73 extracted from

  • Franco, P.; Mastronicola, M.R.; De Cesare, D.; Nolli, M.L.; Wun, T.C.; Verde, P.; Blasi, F.; Stoppelli, M.P.
    Separation and characterization of nonphosphorylated and serine-phosphorylated urokinase. Catalytic properties and sensitivity to plasminogen activator inhibitor type 1 (1992), J. Biol. Chem., 267, 19369-19372.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
plasminogen activator inhibitor 1 phosphorylated enzyme is inhibited 50% at a concentration 4fold higher than nonphosphorylated enzyme Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00092
-
plasminogen phosphorylated enzyme Homo sapiens
0.001
-
plasminogen nonphosphorylated enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
nonphosphorylated and phosphorylated on serine
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell A431 epidermoid carcinoma cells Homo sapiens
-
Detroit 562 cell
-
Homo sapiens
-
ECV304 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
Homo sapiens plasmin + ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
12.4
-
plasminogen nonphosphorylated enzyme Homo sapiens
14.1
-
plasminogen phosphorylated enzyme Homo sapiens