Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | - |
Homo sapiens | |
Tranexamic acid | a synthetic inhibitor efficiently decreasing plasmin activity, plasmin inhibition by tranexamic acid upregulates the profibrogenic genes, which respond to TGF-beta-intracellular signalling | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatic stellate cell | - |
Homo sapiens | - |
HSC-180 cell | originally isolated from a cirrhotic liver | Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
malfunction | plasmin inhibition by tranexamic acid upregulates the profibrogenic genes, which respond to TGF-beta-intracellular signalling | Homo sapiens |
additional information | overexpression of human urokinase plasminogen activator in HSC 180 cells leads to increased plasmin activity, which is blocked by tranexamic acid in the transduced. Plasmin overexpression in the transduced cells significantly decreases gene expression of profibrogenic molecules, i.e. a1(I)collagen by 66%, TIMP-1 by 59%, alpha-smooth muscle actin by 90%, and TGF-beta by 55%. Both SnoN gene and protein expression increased prominently | Homo sapiens |
physiological function | plasmin plays a key role in the regulation of profibrogenic molecules in hepatic stellate cells, role of plasmin in profibrogenic molecule expression, SnoN transcriptional kinetics and gelatinase activation | Homo sapiens |