Literature summary for 3.4.21.7 extracted from

Doeuvre, L.; Plawinski, L.; Goux, D.; Vivien, D.; Angles-Cano, E.
Plasmin on adherent cells: from microvesiculation to apoptosis (2010), Biochem. J., 432, 365-373.

Search for more literature for 3.4.21.7

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	Glu-plasminogen incubated with adherent cells, i.e. CHO-K1, HEK-293 and HMEC-1 cells, is converted into plasmin for activation by constitutively expressed tPA, i.e. tissue-type plasminogen activator, or uPA, i.e. urokinase-type plasminogen activator	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell membrane	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	Glu-plasminogen is cleaved to plasmin for activation by thrombin, as well as by constitutively expressed tPA, i.e. tissue-type plasminogen activator, or uPA, i.e. urokinase-type plasminogen activator	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	plasminogen incubated with adherent cells is converted into plasmin for activation by constitutively expressed tPA, i.e. tissue-type plasminogen activator, or uPA, i.e. urokinase-type plasminogen activator. Plasmin formed on the cell membrane then induces a unique response characterized by membrane blebbing and vesiculation. If plasmin formation persists, matrix proteins are then degraded, cells lose their attachments and enter the apoptotic process, characterized by DNA fragmentation and specific ultrastructural features. In plasminogen-treated cells, the nucleus shows chromatin condensation, the cytoplasm is disorganized, contains lysis vesicles and mitochondria become electron-dense	Homo sapiens

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Release 2023.1 (January 2023)