Literature summary for 3.4.21.7 extracted from

Flight, S.M.; Johnson, L.A.; Du, Q.S.; Warner, R.L.; Trabi, M.; Gaffney, P.J.; Lavin, M.F.; de Jersey, J.; Masci, P.P.
Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss (2009), Br. J. Haematol., 145, 207-211.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Aprotinin	in a mouse tail-vein bleeding model, intravenous textilinin-1 and aprotinin cause similar decreases in blood loss while time to hemostasis in the textilinin-treated animals is significantly shorter	Mus musculus
textilinin-1	potent and reversible inhibition. At 5 microM almost complete inhibition of tissue plasminogen activator-induced fibrinolysis of whole blood clots without affecting the activated partial thromboplastin time for plasma. In a mouse tail-vein bleeding model, intravenous textilinin-1 and aprotinin cause similar decreases in blood loss while time to hemostasis in the textilinin-treated animals is significantly shorter	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

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Release 2023.1 (January 2023)