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Literature summary for 3.4.21.7 extracted from

  • Lei, H.; Velez, G.; Hovland, P.; Hirose, T.; Kazlauskas, A.
    Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy (2008), Invest. Ophthalmol. Vis. Sci., 49, 42-48.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine blocking plasmin prevents the generation of active platelet-derived growth factor-C, which is the major platelet-derived growth factor isoform relevant for proliferative vitreoretinopathy. Thus, plasmin is a therapeutic target for patients with proliferative vitreoretinopathy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha(2)-plasmin inhibitor blocks plasmin activity Homo sapiens
alpha(2)-plasmin inhibitor blocks plasmin activity Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Oryctolagus cuniculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
eye
-
 Homo sapiens
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eye
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 Oryctolagus cuniculus
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serum
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 Homo sapiens
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vitreous humor normal eyes have a low, albeit detectable, level of plasmin. Levels of plasmin are higher in eyes from rabbits with proliferative vitreoretinopathy. Amounts correlate with the stage of proliferative vitreoretinopathy Oryctolagus cuniculus
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vitreous humor vitreous from patients with proliferative vitreoretinopathy have readily detectable levels of plasmin. Presence of plasmin is not unique to patients with proliferative vitreoretinopathy, but also present in a patient undergoing retinal surgery unrelated to proliferative vitreoretinopathy Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
platelet-derived growth factor-C + H2O plasmin is the major protease responsible for processing platelet-derived growth factor-C in patients undergoing retinal surgery. Plasmin is vastly more potent (192times faster) than tissue plasminogen activator in processing the substrate Homo sapiens ?
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 ?
platelet-derived growth factor-C + H2O plasmin is the major protease responsible for processing platelet-derived growth factor-C in rabbits with proliferative vitreoretinopathy Oryctolagus cuniculus ?
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 ?