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Literature summary for 3.4.21.7 extracted from

  • Schaefer, A.V.; Leslie, B.A.; Rischke, J.A.; Stafford, A.R.; Fredenburgh, J.C.; Weitz, J.I.
    Incorporation of fragment X into fibrin clots renders them more susceptible to lysis by plasmin (2006), Biochemistry, 45, 4257-4265.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
fragment X profibrinolytic effect with plasmin. Rates of plasmin formation increase with increasing fragment X concentrations. Plasmin degrades clots containing fragment X more rapidly than fibrin clots Homo sapiens

Application

Application Comment Organism
medicine plasmin can impair hemostasis by partially degrading fibrinogen to fragment X, a product that retains clottability but forms clots with reduced tensile strength that stimulate plasminogen activation by tissue-type plasminogen activator more than fibrin clots. Attenuation of thrombolytic therapy-induced fragment X formation may reduce the risk of bleeding Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha2-antiplasmin inhibitory activity is neutralized by addition of the antibody against alpha2-antiplasmin Homo sapiens
fibrinogen competitive inhibitor of plasmin chromogenic activity Homo sapiens
fragment X competitive inhibitor of plasmin chromogenic activity Homo sapiens
VFK-CMK
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibrin + H2O
-
Homo sapiens ?
-
?
fibrinogen + H2O fragment X generated by limited plasmin digestion of fibrinogen Homo sapiens fragment X
-
?
H-D-Val-Leu-Lys-p-nitroaniline dihydrochloride + H2O
-
Homo sapiens ?
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0038
-
fibrinogen
-
Homo sapiens
0.0095
-
fragment X
-
Homo sapiens