Literature summary for 3.4.21.7 extracted from

Syrovets, T.; Simmet, T.
Novel aspects and new roles for the serine protease plasmin (2004), Cell. Mol. Life Sci., 61, 873-885.

Search for more literature for 3.4.21.7

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	zymogen: plasminogen	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the plasminogen activation system is mostly recognized for its fibrinolytic activity but is also upregulated in chronic inflammatory diseases, including atherosclerosis and arthritis. Plasmin is a potent activator of human monocytes and a number of other cells. In monocytes plasmin elicits full-blown proinflammatory activation encompassing lipid mediator release, chemotaxis and induction of cytokines and other proinflammatory genes. Cell activation is dependent on the binding of the plasmin molecule via its lysine binding sites as well as on the intact catalytic center of plasmin, indicating proteolytic activation. Cell activation occurs through a yet unidentified receptor which is specific for plasmin and that, at least in monocytes, is not activated by other proteases, such as factor Va and Xa, the serine proteases thrombin, alpha-chymotrypsin, human neutrophil elastase or cathepsin G	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)