Literature summary for 3.4.21.7 extracted from

Brown, E.W.; Ravindran, S.; Patston, P.A.
The reaction between plasmin and C1-inhibitor results in plasmin inhibition by the serpin mechanism (2002), Blood Coagul. Fibrinolysis, 13, 711-714.

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Inhibitors

Inhibitors	Comment	Organism	Structure
C1 inhibitor	the C1-inhibitor in its native state inhibits plasmin without significant degradation. If the C1-inhibitor is in a denatured polymeric state as can easily occur during storage, or as produced by heating of the native protein, it will be extensively degraded by plasmin	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
C1 inhibitor + H2O	the C1-inhibitor in its native state inhibits plasmin without significant degradation. If the C1-inhibitor is in a denatured polymeric state as can easily occur during storage, or as produced by heating of the native protein, it will be extensively degraded by plasmin	Homo sapiens	?	-	?
chromogenic substrate S-2551 + H2O	-	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)