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Literature summary for 3.4.21.53 extracted from

  • Quiros, P.M.; Espanol, Y.; Acin-Perez, R.; Rodriguez, F.; Barcena, C.; Watanabe, K.; Calvo, E.; Loureiro, M.; Fernandez-Garcia, M.S.; Fueyo, A.; Vazquez, J.; Enriquez, J.A.; Lopez-Otin, C.
    ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity (2014), Cell Rep., 8, 542-556.
    View publication on PubMed
Search for more literature for 3.4.21.53

Application

Application Comment Organism
diagnostics high levels of LONP1 are a poor prognosis marker in human colorectal cancer and melanoma Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene Lonp1 Homo sapiens
gene Lonp1 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information homozygous deletion of gene Lonp1 Homo sapiens
additional information homozygous deletion of gene Lonp1 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene Lonp1
-
Mus musculus Q8CGK3 gene Lonp1
-

Source Tissue

Source Tissue Comment Organism Textmining
colon cancer cell
-
 Mus musculus
-
colonic cancer cell
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
melanoma cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
ATP-dependent lon protease
-
 Homo sapiens
ATP-dependent lon protease
-
 Mus musculus
lon protease
-
 Homo sapiens
lon protease
-
 Mus musculus
LONP1
-
 Homo sapiens
LONP1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction homozygous deletion of Lonp1 causes early embryonic lethality, whereas its haploinsufficiency protects against colorectal and skin tumors. LONP1 knockdown inhibits cellular proliferation and tumor and metastasis formation, phenotypes, overview. LONP1 is necessary for proliferation and metastasis of melanoma cells Mus musculus
malfunction overexpression of the enzyme increases tumorigenesis, high levels of LONP1 are a poor prognosis marker in human colorectal cancer and melanoma, phenotypes, overview Homo sapiens
physiological function the enzyme plays a key role in metabolic reprogramming by remodeling OXPHOS complexes and protecting against senescence. The protease is a central regulator of mitochondrial activity in oncogenesis. LONP1 is necessary for proliferation and metastasis of melanoma cells Homo sapiens
physiological function the enzyme plays a key role in metabolic reprogramming by remodeling OXPHOS complexes and protecting against senescence. The protease is a central regulator of mitochondrial activity in oncogenesis. Role of LONP1 in the regulation of mitochondrial function in cancer, overview Mus musculus