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Literature summary for 3.4.21.53 extracted from
- Mitochondrial calpain 10 is degraded by Lon protease after oxidant injury (2012), Arch. Biochem. Biophys., 517, 144-152.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| H2O2 | activation is not inhibited by MG132 | Oryctolagus cuniculus |  |
| tert-butyl hydroperoxide | activation is inhibited by MG132 | Oryctolagus cuniculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| MG132 | causes calpain 10 accumulation in vivo | Oryctolagus cuniculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Oryctolagus cuniculus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| calpain 10 + H2O | Oryctolagus cuniculus | degradation of the mitochondrial matrix protease | ? | - |
? | |
| calpain 10 + H2O | Oryctolagus cuniculus New Zealand White | degradation of the mitochondrial matrix protease | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
| Oryctolagus cuniculus New Zealand White | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| renal cortex | - |
Oryctolagus cuniculus | - |
| renal proximal tubule | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| calpain 10 + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| calpain 10 + H2O | degradation of the mitochondrial matrix protease | Oryctolagus cuniculus | ? | - |
? | |
| calpain 10 + H2O | - |
Oryctolagus cuniculus New Zealand White | ? | - |
? | |
| calpain 10 + H2O | degradation of the mitochondrial matrix protease | Oryctolagus cuniculus New Zealand White | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lon protease | - |
Oryctolagus cuniculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at, in vivo | Oryctolagus cuniculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | mitochondrial calpain 10 is selectively degraded by Lon protease under basal conditions and is enhanced under and oxidizing conditions, while cytosolic calpain 10 is degraded by the proteasome | Oryctolagus cuniculus |
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