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BRENDA support

Literature summary for 3.4.21.53 extracted from

  • Bender, T.; Lewrenz, I.; Franken, S.; Baitzel, C.; Voos, W.
    Mitochondrial enzymes are protected from stress-induced aggregation by mitochondrial chaperones and the Pim1/LON protease (2011), Mol. Biol. Cell, 22, 541-554.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Saccharomyces cerevisiae 5739
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

General Information

General Information Comment Organism
physiological function mitochondrial proteins aggregate to a substantial extent if they are challenged by either heat stress or reactive oxygen. As an important aspect of quality control, the proteolytic activity of Pim1 prevents the accumulation of these aggregation-prone polypeptides, resulting in prevention of proteotoxic effects Saccharomyces cerevisiae