Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Arabidopsis thaliana | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | O64948 | isoform LON2 | - |
General Information | Comment | Organism |
---|---|---|
physiological function | a lon2 disruption mutant is mildly resistant to the inhibitory effects of indole-3-butyric acid on root elongation, resistant to the stimulatory effects of indole-3-butyric acid on lateral root production and display succinate dependence during seedling growth. lon2 mutants display defects in removing the type 2 peroxisome targeting signal PTS2 from peroxisomal malate dehydrogenase and reduced accumulation of 3-ketoacyl-CoA thiolase, another PTS2-containing protein, both defects are not apparent upon germination but appear in 5 to 8 days old seedlings. In lon2 cotyledon cells, matrix proteins are localized to peroxisomes in 4 days old seedlings but mislocalized to the cytosol in 8 days old seedlings. A PTS2-green fluorescent protein reporter sorts to peroxisomes in lon2 root tip cells but is largely cytosolic in more mature root cells. LON2 is needed for sustained matrix protein import into peroxisomes | Arabidopsis thaliana |