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Literature summary for 3.4.21.53 extracted from
- The Lon protease regulates swarming motility and virulence gene expression in Proteus mirabilis (2008), J. Med. Microbiol., 57, 931-937.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mini-Tn5lacZ1 transposon insertion in the Lon protease gene confers a hyper-swarming phenotype on Proteus mirabilis. The lon mutation increases the accumulation of mRNA for representative class 1, flhDC, class 2, fliA, and class 3, flaA genes during swarmer cell differentiation. In addition, the stability of the FlhD protein is fourfold higher in the lon::mini-Tn5lacZ1 background. Expression of a single-copy lon::lacZ fusion increases during the swarming cycle and reaches peak levels of expression at a point just after swarmer cell differentiation has initiated. In liquid media, the lon::mini-Tn5lacZ1 insertion results in motile, highly elongated cells that overexpress flagellin. The lon::mini-Tn5lacZ1 mutation results in increased expression of the hpmBA and zapA virulence genes during swarmer cell differentiation | Proteus mirabilis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Proteus mirabilis | - |
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Release 2023.1 (January 2023)
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