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Literature summary for 3.4.21.53 extracted from
- The ATP-dependent Lon protease of Mus musculus is a DNA-binding protein that is functionally conserved between yeast and mammals (2003), Gene, 306, 45-55.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Lon cDNA cloned and expressed in yeast strain PIM1, complementing a LON deletion, also overexpressed in COS-7 cells | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 100000 | - |
- |
Homo sapiens |
| 100000 | - |
immunoblotting | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Mus musculus | - |
mouse | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
| recombinant enzyme | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Mus musculus | phosphate + ADP | - |
? |  |
| ATP + H2O | - |
Homo sapiens | phosphate + ADP | - |
? | |
| additional information | mediates the degradation of misfolded, unassembled or oxidatively damaged polypeptides, not only degrades protein substrates but also binds DNA, specifically binds to single stranded but not to double-stranded DNA oligonucleotides | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lon protease | - |
Mus musculus |
| lon protease | - |
Homo sapiens |
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