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Literature summary for 3.4.21.53 extracted from
- ATP hydrolysis is not stoichiometrically linked with proteolysis in the ATP-dependent protease La from Escherichia coli (1993), J. Biol. Chem., 268, 22502-22507.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Dimethylsulfoxide | activation | Escherichia coli |  |
| Polyethylene glycol | activation | Escherichia coli | |
| Tween 20 | activation | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
wild-type strain W3110 and mutant strain | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Glutaryl-Ala-Ala-Phe-methoxynaphthylamide + H2O | - |
Escherichia coli | Glutaryl-Ala-Ala-Phe + methoxynaphthylamine | - |
? | |
| additional information | with a proteolytic and an ATP-binding site per monomer | Escherichia coli | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | proteolytically inactive mutant enzyme with completely unaffected ATPase activity | Escherichia coli | |
| ATP | ATP-dependent protease | Escherichia coli | |
| ATP | ATP hydrolysis is not stoichiometrically linked with proteolysis | Escherichia coli | |
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