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Literature summary for 3.4.21.5 extracted from

  • Dangwal, S.; Rauch, B.H.; Gensch, T.; Dai, L.; Bretschneider, E.; Vogelaar, C.F.; Schroer, K.; Rosenkranz, A.C.
    High glucose enhances thrombin responses via protease-activated receptor-4 in human vascular smooth muscle cells (2011), Arterioscler. Thromb. Vasc. Biol., 31, 624-633.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
D-glucose high glucose enhances thrombin responses through transcriptional upregulation of protease-activated receptor-4, PAR-4, mediated via PKC-beta, -delta, and NFkappaB, in human vascular smooth muscle cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell
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Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens enhancement of thrombin-stimulated migration and gene expression by high glucose, which can be abolished by endogenous protease-activated receptor-4, PAR-4, knockdown up

General Information

General Information Comment Organism
malfunction high glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, which may play an important role in the vascular complications of diabetes Homo sapiens
physiological function thrombin evokes Ca2+ signaling in smooth muscle cell and induces smooth muscle cell migration and tumor necrosis factor alpha gene expression Homo sapiens