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Literature summary for 3.4.21.5 extracted from

  • Wang, Z.; Kong, L.; Kang, J.; Morgan, J.H.; Shillcutt, S.D.; Robinson, J.S.; Nakayama, D.K.
    Thrombin stimulates mitogenesis in pig cerebrovascular smooth muscle cells involving activation of pro-matrix metalloproteinase-2 (2009), Neurosci. Lett., 451, 199-203.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
fibrin + fibrinopeptide A + fibrinopeptide B
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
?

Synonyms

Synonyms Comment Organism
alpha-thrombin
-
Homo sapiens

General Information

General Information Comment Organism
physiological function thrombin does not affect expression of cell-associated pro-matrix metalloproteinase-2 (pro-MMP-2) protein. Thrombin activates pro-MMP-2 in the absence of elevated pro-MMP-2 expression and secretion in CSMCs, and thrombin induces cerebrovascular smooth muscle cells mitogenesis involving its action on MMP-2 Homo sapiens