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Literature summary for 3.4.21.5 extracted from
- Direct thrombin inhibitors: pharmacology and application in intensive care medicine (2010), Intensive Care Med., 36, 1127-1137.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| argatroban | reversible thrombin inhibitor | Homo sapiens |  |
| bivalirudin | reversible bivalent thrombin inhibitor | Homo sapiens | |
| dabigatran etexilate | - |
Homo sapiens | |
| heparin | - |
Homo sapiens | |
| Hirudin | irreversible, bivalent thrombin inhibitor | Homo sapiens | |
| lepirudin | reversible bivalent thrombin inhibitor | Homo sapiens | |
| ximelagatran | prodrug of melagatran | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibrinogen + H2O | Homo sapiens | - |
fibrin + fibrinopeptide A + fibrinopeptide B | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibrinogen + H2O | - |
Homo sapiens | fibrin + fibrinopeptide A + fibrinopeptide B | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| clotting factor IIa | - |
Homo sapiens |
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