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Literature summary for 3.4.21.5 extracted from

  • Green, D.; Karpatkin, S.
    Role of thrombin as a tumor growth factor (2010), Cell Cycle, 9, 656-661.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Hirudin
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
fibrin + fibrinopeptide A + fibrinopeptide B
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
?

General Information

General Information Comment Organism
malfunction in the transgenic TRAMP mouse model of prostate cancer inhibition of endogenous thrombin by hirudin retards spontaneous tumor growth. Inhibition of thrombin may lead to tumor dormancy Homo sapiens
physiological function thrombin is the key terminal enzyme of coagulation, does also promote angiogenesis and stimulates tumor-platelet adhesion, adhesion to endothelium, tumor implantation, tumor cell growth and metastasis. Thrombin also exerts direct effects on cancer cells by activation of the cell cycle through downregulation of p27(Kip1) and induction of Skp2, and cyclins D and A. MicroRNA 222, which inhibits p27(Kip1), is upregulated by thrombin Homo sapiens