Literature summary for 3.4.21.5 extracted from

Kastl, S.P.; Speidl, W.S.; Katsaros, K.M.; Kaun, C.; Rega, G.; Assadian, A.; Hagmueller, G.W.; Hoeth, M.; de Martin, R.; Ma, Y.; Maurer, G.; Huber, K.; Wojta, J.
Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation (2009), Blood, 114, 2812-2818.

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Inhibitors

Inhibitors	Comment	Organism	Structure
D-Phe-Pro-Arg-chloromethylketone	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
alpha-thrombin	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	thrombin induces the expression of oncostatin M via AP-1 activation in human monocyte-derived macrophages, peripheral blood monocytes, and human plaque macrophages up to 16.8fold after 24 h. Thrombin induces phosphorylation of ERK1/2 and p38 in monocyte-derived macrophages. A functional AP-1 site is required for oncostatin M promoter activation by thrombin	Homo sapiens

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Release 2023.1 (January 2023)