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Literature summary for 3.4.21.5 extracted from

  • Doria, C.; Fischer, C.P.; Wood, C.G.; Li, P.M.; Marra, S.; Hart, J.
    Phase 3, randomized, double-blind study of plasma-derived human thrombin versus bovine thrombin in achieving hemostasis in patients undergoing surgery (2008), Curr. Med. Res. Opin., 24, 785-794.
    View publication on PubMed

Application

Application Comment Organism
medicine treatment of adults with one or more mild or moderate bleeding sites not manageable by conventional modalities during elective cardiovascular, neurologic, or general surgey procedures with human or bovine thrombin, applied topically with an absorbable gelatin sponge. The proportions of patients achieving hemostasis within 10 min, 6 min or 3 min were equivalent for human and bovine thrombin.12.7% of patients who received bovine thrombin demonstrated seroconversion compared with 3.3% of the patients who received human thrombin Bos taurus
medicine treatment of adults with one or more mild or moderate bleeding sites not manageable by conventional modalities during elective cardiovascular, neurologic, or general surgey procedures with human or bovine thrombin, applied topically with an absorbable gelatin sponge. The proportions of patients achieving hemostasis within 10 min, 6 min or 3 min were equivalent for human and bovine thrombin.12.7% of patients who received bovine thrombin demonstrated seroconversion compared with 3.3% of the patients who received human thrombin. None of the patients in the human thrombin group developed seroconversion for anti-human thrombin or anti-human factor V/Va antibodies Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
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Homo sapiens
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