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Literature summary for 3.4.21.5 extracted from

  • Stief, T.W.
    Specific determination of plasmatic thrombin activity (2006), Clin. Appl. Thromb. Hemost., 12, 324-329.
    View publication on PubMed
Search for more literature for 3.4.21.5

Protein Variants

Protein Variants Comment Organism
additional information lack of thrombin generation in factor II-deficient plasma Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens thrombin is the key enzyme of coagulation fibrin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma low levels of activated thrombin, overview Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 assay method optimization with synthetic substrate HD-cyclohexylglycyl-Ala-Arg-4-nitroanilide, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
 Homo sapiens fibrin + ?
-
 ?
fibrinogen + H2O thrombin is the key enzyme of coagulation Homo sapiens fibrin + ?
-
 ?
HD-cyclohexylglycyl-Ala-Arg-4-nitroanilide + H2O assay method optimization with synthetic substrate HD-cyclohexylglycyl-Ala-Arg-4-nitroanilide, overview Homo sapiens HD-cyclohexylglycyl-Ala-Arg + 4-nitroaniline
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.6
-
 assay at Homo sapiens