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Literature summary for 3.4.21.5 extracted from

  • Pineda, A.O.; Chen, Z.W.; Caccia, S.; Cantwell, A.M.; Savvides, S.N.; Waksman, G.; Mathews, F.S.; Di Cera, E.
    The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket (2004), J. Biol. Chem., 279, 39824-39828.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
mutant W215A/E217A, free and in complex with inhibitor D-Phe-Pro-Arg-chloromethylketone Homo sapiens

Protein Variants

Protein Variants Comment Organism
W215A/E217A drastically impaired catalytic activity, but able to efficiently activate protein C in presence of thrombomodulin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
D-Phe-Pro-Arg-chloromethylketone
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00734
-
-