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Literature summary for 3.4.21.5 extracted from

  • Buchanan, M.R.; Maclean, G.A.; Brister, S.J.
    Selective and sustained inhibition of surface-bound thrombin activity by intimatan/heparin cofactor II and its relevance to assessing systemic anticoagulation in vivo, ex vivo and in vitro (2001), Thromb. Haemost., 86, 909-913.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
heparin from porcine mucosa, inhibitory effect on fluid-phase and surface-bound thrombin in vivo in rabbits and in vitro Bos taurus
heparin from porcine mucosa, inhibitory effect on fluid-phase and surface-bound thrombin in vivo in rabbits and in vitro Homo sapiens
heparin cofactor II inhibitory effect on fluid-phase and surface-bound thrombin Bos taurus
heparin cofactor II inhibitory effect on fluid-phase and surface-bound thrombin Homo sapiens
Intimatan heparin cofactor II agonist, inhibitory effect on fluid-phase and surface-bound thrombin in vivo in rabbits and in vitro Bos taurus
Intimatan heparin cofactor II agonist, inhibitory effect on fluid-phase and surface-bound thrombin in vivo in rabbits and in vitro Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
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Homo sapiens
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prothrombin
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O i.e. S2238, synthetic chromogenic substrate Homo sapiens D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline
-
?
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O i.e. S2238, synthetic chromogenic substrate Bos taurus D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline
-
?