Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.4 extracted from

  • Mao, Y.; Kunapuli, S.P.
    Trypsin causes platelet activation independently of known protease-activated receptors (2013), Thromb. Haemost., 110, 1241-1249.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.4

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Sus scrofa
-
pancreas
-
 Sus scrofa
-

General Information

General Information Comment Organism
physiological function trypsin activates PAR4 null murine platelets. Trypsin causes shape change without increasing intracellular calcium levels in PAR4 null murine platelets. Trypsin-induced platelet shape change is abolished by either p160ROCK inhibitor, Y27632 or H1152. Trypsin causes phosphorylation of myosin light chain (Thr18), but not Akt or Erk. Trypsin causes a similar shape change in PAR4-desensitized PAR3 null murine platelets as in PAR4 null murine platelets, indicating that trypsin does not activate PAR3 to cause shape change. The Src family kinase inhibitor PP2 abolishes trypsin-induced, but not AYPGKF-induced, shape change Sus scrofa