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Literature summary for 3.4.21.4 extracted from

  • Park, H.; Chi, Y.M.
    The enhancement of electrostriction caused by lowering the solvent dielectric constant leads to the decrease of activation energy in trypsin catalysis (2001), Biochim. Biophys. Acta, 1568, 53-59.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information increase in catalytic efficiency of the trypsin reaction with decreasing dielectric constant results from the stabilization of electrostatic energy for the formation of an oxyanion hole, and this stabilization is caused by the increase of electrostricted water around the charged tetrahedral transition state. The control of the solvent dielectric constant can stabilize the tetrahedral transition state, and this lowers the activation energy Bos taurus

General Stability

General Stability Organism
decreasing dielectric constant results from the stabilization of electrostatic energy for the formation of an oxyanion hole, and this stabilization is caused by the increase of electrostricted water around the charged tetrahedral transition state. The control of the solvent dielectric constant can stabilize the tetrahedral transition state, and this lowers the activation energy Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
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