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Literature summary for 3.4.21.122 extracted from

  • Shulla, A.; Heald-Sargent, T.; Subramanya, G.; Zhao, J.; Perlman, S.; Gallagher, T.
    A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry (2011), J. Virol., 85, 873-882 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.122

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293T cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
S441A inactive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15393
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alveolar epithelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin-converting enzyme ACE2 + H2O
-
 Homo sapiens ?
-
 ?
SARS coronavirus spike protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
transmembrane protease/serine subfamily member 2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function angiotensin-converting enzyme ACE2 and TMPRSS2 colocalize on cell surfaces and enhance the cell entry of both SARS S-pseudotyped HIV and authentic SARS-CoV. Enhanced entry correlates with TMPRSS2-mediated proteolysis of both S protein and ACE2 Homo sapiens