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Literature summary for 3.4.21.109 extracted from

  • Benaud, C.; Dickson, R.B.; Lin, C.Y.
    Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor (2001), Eur. J. Biochem., 268, 1439-1447.
    View publication on PubMed
Search for more literature for 3.4.21.109

Activating Compound

Activating Compound Comment Organism Structure
serum from human, horse, mouse, rat, rabbit, duck, chicken, goat, calf, turtle and foetal bovine serum, leads to increase of the level of the active two-chain form Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
hepatocyte growth factor activator inhibitor-1 i.e. HAI-1, binding is reversible and acid labile Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
 1 * 70000 + 1 * 240000, complex purified from milk, SDS-PAGE Homo sapiens
80000
-
 noncomplexed form purified from T47D cells, SDS-PAGE Homo sapiens
95000
-
 complexed with HAI-1, purified from milk, SDS-PAGE Homo sapiens
240000
-
 1 * 70000 + 1 * 240000, complex purified from milk, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens degrades extracellular matrix ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y5Y6
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification zymogen is activated by proteolytic cleavage Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
184A1N4 cell nontumorigenic mammary epithelial cells Homo sapiens
-
epithelial cell
-
 Homo sapiens
-
mamma
-
 Homo sapiens
-
MCF-10A cell
-
 Homo sapiens
-
milk
-
 Homo sapiens
-
T47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information degrades extracellular matrix Homo sapiens ?
-
 ?
N-tert-butoxy-carbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin
-
 Homo sapiens N-tert-butoxy-carbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 70000 + 1 * 240000, complex purified from milk, SDS-PAGE Homo sapiens
monomer 1 * 80000 noncomplexed enzyme from T47D cells, SDS-PAGE Homo sapiens