Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | upon LeuLeuOMe treatment, which induces lysosomal membrane permeabilization, lysosomal chymotrypsin is relocated to the cytosol | Homo sapiens | 5829 | - |
lysosome | chymotrypsin colocalizes with the lysosomal marker protein LAMP1 | Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
calcineurin + H2O | - |
Homo sapiens | ? | chymotrypsin cleaves calcineurin into a 47-kDa fragment and a 13-kDa fragment, the cleavage activates the phosphatase activity of calcineurin in a Ca2+/CaM-independent manner | ? |
General Information | Comment | Organism |
---|---|---|
physiological function | intracellular delivery of chymotrypsin significantly potentiates apoptosis, and chymotrypsin is involved in mitochondrial fission during apoptosis. Chymotrypsin cleaves calcineurin into a 47-kDa fragment and a 13-kDa fragment, the cleavage activates the phosphatase activity of calcineurin in a Ca2+/CaM-independent manner. Cleaved calcineurin induces the translocation of cytosolic Drp1 to the mitochondria and triggers significant mitochondrial fission | Homo sapiens |