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Literature summary for 3.4.21.1 extracted from

  • Perveen, S.; Mustafa, S.; Latif, M.; Iqbal, L.; Usmani, T.; Khan, K.; Voelter, W.
    Unsymmetrical 1,3-disubstituted urea derivatives as alpha-chymotrypsin inhibitors (2014), Med. Chem. Res., 23, 3585-3592.
No PubMed abstract available
Search for more literature for 3.4.21.1

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibitory activity of the urea compounds synthesized depends upon the position of the methyl group at the phenyl ring and the presence of substituents at the nitrogen of the urea bridge. The inhibitory trend suggests that alpha-chymotrypsin inhibitory activity declines with ortho, meta, para substitution order Bos taurus
N-(2-acetylphenyl)-N'-(3-methylphenyl) urea
-
 Bos taurus
N-(2-methylphenyl)-2-oxo-1-pyrrolidine carboxamide most active inhibitor Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus P00766
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Bos taurus
-
pancreas
-
 Bos taurus
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00824
-
 pH 7.6, 25°C Bos taurus N-(2-methylphenyl)-2-oxo-1-pyrrolidine carboxamide
0.0136
-
 pH 7.6, 25°C Bos taurus N-(2-acetylphenyl)-N'-(3-methylphenyl) urea