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Literature summary for 3.4.21.1 extracted from

  • Linington, R.G.; Edwards, D.J.; Shuman, C.F.; McPhail, K.L.; Matainaho, T.; Gerwick, W.H.
    Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp (2008), J. Nat. Prod., 71, 22-27.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.1

Inhibitors

Inhibitors Comment Organism Structure
additional information overview about structure-activity relationships for all Ahp-containing depsipeptides with inhibitory activity against trypsin or chymotrypsin Homo sapiens
N-benzoyl-L-tyrosine ethyl ester
-
 Homo sapiens
symplocamide A from the Marine Cyanobacterium Symploca sp.. A potent cancer cell cytotoxin, which also inhibits serine proteases with a 200fold greater inhibition of chymotrypsin over trypsin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NCI-H460 cell lung cancer cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzoyl-L-tyrosine ethyl ester + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
chymotrypsin
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00038
-
-
 Homo sapiens N-benzoyl-L-tyrosine ethyl ester