Cloned (Comment) | Organism |
---|---|
ACE2 expression analysis by RT-PCR | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | ACE2 is insensitive to ACE inhibitors | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | Rattus norvegicus | - |
angiotensin(1-7) + L-Phe | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
connective tissue | - |
Rattus norvegicus | - |
hepatic stellate cell | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | - |
Rattus norvegicus | angiotensin(1-7) + L-Phe | - |
? | |
angiotensin II + H2O | i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | Rattus norvegicus | angiotensin(1-7) + L-Phe | i.e. Asp-Arg-Val-Tyr-Ile-His-Pro | ? |
Synonyms | Comment | Organism |
---|---|---|
ACE2 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | the enzyme expression is upregulated in case of induced liver fibrosis and is further upregulated by additional administration of ACE I inhibitor peptide, pGlu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, in hepatic stellate cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | ACE 2 balances the status of the renin-angiotensin system by degrading angiotensin II and generating angiotensin-(1-7). ACE2 induces overexpression of connective tissue growth factor, which is inhibited by blockade of theMas receptor with A779, overview | Rattus norvegicus |