Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.17.1 extracted from

  • Wang, S.F.; Tian, G.R.; Zhang, W.Z.; Jin, J.Y.
    Characterization of alpha-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase A (2009), Bioorg. Med. Chem. Lett., 19, 5009-5011.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
(R)-2-benzyl-5-nitro-4-oxopentanoic acid
-
Bos taurus
(S)-2-benzyl-5-nitro-4-oxopentanoic acid
-
Bos taurus
2-benzyl-4-oxopentanoic acid
-
Bos taurus
2-benzyl-5,5,5-trifluoro-4-oxopentanoic acid
-
Bos taurus
2-benzyl-5-bromo-4-oxopentanoic acid
-
Bos taurus
2-benzylsuccinic acid potent inhibitor Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus P00730
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-(trans-4-chlorocinnamoyl)-L-beta-phenyllactate + H2O
-
Bos taurus trans-4-chlorocinnamic acid + L-phenyllactic acid
-
?

Synonyms

Synonyms Comment Organism
CPA
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00016
-
(S)-2-benzyl-5-nitro-4-oxopentanoic acid in 0.05 M Tris/0.5 M NaCl buffer, pH 7.5 Bos taurus
0.0002
-
2-benzyl-5,5,5-trifluoro-4-oxopentanoic acid in 0.05 M Tris/0.5 M NaCl buffer, pH 7.5 Bos taurus
0.00043
-
(R)-2-benzyl-5-nitro-4-oxopentanoic acid in 0.05 M Tris/0.5 M NaCl buffer, pH 7.5 Bos taurus
0.015
-
2-benzyl-5-bromo-4-oxopentanoic acid in 0.05 M Tris/0.5 M NaCl buffer, pH 7.5 Bos taurus
0.207
-
2-benzyl-4-oxopentanoic acid in 0.05 M Tris/0.5 M NaCl buffer, pH 7.5 Bos taurus